CCO Infectious Disease Podcast

Key Decisions in HIV Care: Polypharmacy and Cardiovascular Risk Considerations in Older PWH

Episode Summary

In this on-demand recording of a live webinar, expert faculty review key considerations for the use of ART in older PWH. Topics include current data and recommendations on polypharmacy, drug–drug interactions, drug–disease state interactions, and cardiovascular risk considerations.

Episode Notes

In this episode from the series “Key Decisions in HIV Care,” Jonathan Appelbaum, MD, FACP, AAHIVS, and Jens D. Lundgren, MD, DMSc, discuss important considerations for ART use in older PWH, including:

• DHHS, EACS, IAS, and WHO recommendations for first-line ART
• Virologic outcomes for older PWH in clinical trials and results from the HealthHIV Second Annual National Survey
• Polypharmacy and its potential consequences, including common non-ARV medications prescribed in the VACS cohort, drug–drug interactions with common concomitant medications, common comorbidities in older PWH, and drug–disease state interactions including renal and hepatic impairment
• Cardiovascular risk considerations including data from the D:A:D study and RESPOND cohort and lipid changes in the TANGO study of switching to DTG/3TC from TAF-based ART

Presenters:

Jonathan Appelbaum, MD, FACP, AAHIVS
Laurie L. Dozier Jr, MD, Education Director
Professor of Internal Medicine  
Chair, Department of Clinical Sciences
Florida State University College of Medicine
Tallahassee, Florida  

Jens D. Lundgren, MD, DMSc
Professor
Rigshospital, University of Copenhagen
Copenhagen, Denmark
Director
Centre of Excellence for Health, Immunity and Infection (CHIP)
Rigshospital, University of Copenhagen
Copenhagen, Denmark  

Content based on an online CME program supported by educational grants from Gilead Sciences, Inc.; Janssen Therapeutics, Division of Janssen Products, LP; and ViiV Healthcare.

Follow along with the slides at:
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See the entire program at: 
https://bit.ly/2TXTYWx