CCO Infectious Disease Podcast

Choosing Between Initial ART Options: Answering the Questions

Episode Summary

Drs Marta Boffito and Michelle Cespedes discuss questions about first-line antiretroviral therapy, from Clinical Care Options (CCO)

Episode Notes

In this episode, Marta Boffito, MD, PhD, FRCP, and Michelle Cespedes, MD, MS, discuss initial ART options, including:

• Recommended first-line ART options for most PWH according to DHHS, IAS-USA, EACS, BHIVA, and WHO guidelines 
• Data for weight gain after ART initiation with different ARV classes and drugs
• Weight gain disparities by race and gender after ART initiation
• Data from the RESPOND study including risk factors for weight gain and CV event risk with INSTI vs non-INSTI–based ART 
• The impact of INSTIs on CV events in the Swiss HIV Cohort study 
• Recommendations for ART and contraception for PWH of childbearing potential 
• Drug–drug interactions between first-line ART and contraceptive options 
• Guideline-recommended first-line ART options in pregnancy with a discussion of how these regimens differ from those recommended for most PWH 

Marta Boffito, MD, PhD, FRCP 
Consultant Physician 
Clinical Director, HIV, Sexual and Gender Health, Dermatology 
Chelsea and Westminster Hospital NHS Foundation Trust 
Imperial College London 
London, United Kingdom 

Michelle Cespedes, MD, MS 
Professor of Medicine 
Division of Infectious Disease 
Department of Medicine 
Icahn School of Medicine at 
Mount Sinai 
New York, New York 

Link to full program: bit.ly/3HPu4Lk